Bah humbug

Choice? Bah! Humbug!

Control not at initiation? Bah, humbug!

Initiation is often assumed to be rate-limiting for protein synthesis, but the presence of rare codons nonetheless can influence protein levels. In this issue of The EMBO Journal, Chu et al report that when rare codons are positioned near the start of the coding region, 'liberation' of the initiation codon for loading of the next 40S subunit may be rate‐limiting for initiation and therefore ove...

Bah humbug: Unexpected Christmas cards and the reciprocity norm.

The reciprocity norm refers to the expectation that people will help those who helped them. A well-known study revealed that the norm is strong with Christmas cards, with 20% of people reciprocating a Christmas card received from a stranger. I attempted to conceptually replicate and extend this effect. In Study 1, 755 participants received a Christmas card supposedly from a more- versus less-si...

Two ’ s company : “ The humbug of many logical values ”

The Polish logician Roman Suszko has extensively pleaded in the 1970s for a restatement of the notion of many-valuedness. According to him, as he would often repeat, “there are but two logical values, true and false.” As a matter of fact, a result by Wójcicki-Lindenbaum shows that any tarskian logic has a many-valued semantics, and results by Suszko-da Costa-Scott show that any many-valued sema...

Structure and function of the BAH domain in chromatin biology.

Proteins containing Bromo Adjacent Homology (BAH) domain are often associated with biological processes involving chromatin, and mutations in BAH domains have been found in human diseases. A number of structural and functional studies have revealed that the BAH domain plays diverse and versatile roles in chromatin biology, including protein-protein interactions, recognition of methylated histon...